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KMID : 0371320000590050602
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Journal of the Korean Surgical Society
2000 Volume.59 No. 5 p.602 ~ p.608
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Prognostic Significance of DNA Content and S-Phase Fraction in Gastric Carcinomas
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Hwang Su-Kyung
Lee Jun-Ho
Noh Sung-Hoon
Rhee Kang-Young
Choi Seung-Ho
Min Jin-Sik
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Abstract
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Purpose :DNA flow cytometry is a simple and easy method to assess the DNA content and the cell-cycle distribution of a tumor cell. The prognostic significance of the DNA content and the S-phase fraction in a gastric carcinoma has been controversial. The purpose of this study was to evaluate the prognostic significance of the nuclear DNA content and the S-phase fraction in patients with a gastric carcinoma.
Methods :Between May 1995 and March 1996, 94 patients who were underwent a gastric resection for a gastric carcinoma were evaluated with DNA flow cytometry. Of them, 88 patients underwent a gastric resection with curativeintent. The relationship of variable clinicopathological factors and of recurrence pattern to survival and nuclear DNA content were assessed.
Results :The mean age was 55 years. 55 patients (58.5%) exbitied diploidy and 39 patients (41.5%) aneuploidy. There was no relationship between the clinicopathological factors and either the ploidy pattern or the S-phase fraction.
Though the recurrence and its pattern were not different between the two ploidy group (p=0.860, 0.137), diploidy tended to recur locoregionally and aneuploidy hematogenously.
Conclusion :The ploidy pattern was a significant prognostic factor in gastric carcinomas, but should be interpreted carefully.
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KEYWORD
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Gastric carcinoma, Prognosis, DNA flow cytometry,
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